Endocrine Abstracts

Corticotropin Releasing Hormone (CRH) is the hypothalamic mediator of the stress response that ultimately results in increased release of glucocorticoid. CRH exerts its effects by binding to the CRH receptors 1 and 2 that belong to the family of the GPCRs. As we and others have shown in rodent and human tissues, peripherally expressed CRH is a potent proinflammatory factor. The immunomodulatory effects of CRH are exerted by its activation of the NF-κB DNA binding activity...